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The Tissue clearing of the Vascular
The vascular system represents a complex three-dimensional (3D) structure. A high-resolution 3D imaging method of uniform quality without specimen distortion is highly required. The tissue clearing techonology make the selected structures visible in three dimensions in a non-destructive manner, which helps to understand normal and pathological anatomy. 

Here are some papers on the vascular use of the Binaree tissue clearing technology and others.
Extracellular RNAs in periodontopathogenic outer membrane vesicles promote TNF-α production in human macrophages and cross the blood-brain barrier in mice. 
FASEB Journal. 2019 Dec;33(12):13412-13422. doi: 10.1096/fj.201901575R. Epub 2019 Sep 21.
Eun-Chong Han, Song-Yi Choi, Youngkyun Lee, Jin-Woo Park, Su-Hyung Hong, Heon-Jin Lee

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Three-dimensional visualization of cerebral blood vessels and neural changes in thick ischemic rat brain slices using tissue clearing
Scientific Reports, 2022 Sep 23;12(1):15897. doi: 10.1038/s41598-022-19575-w. 
Eun-Joo Lee, Sung-Kuk Hong, Dong-Hwa Choi, Sang-Il Gum, Mee Yul Hwang, Dong Sun Kim, Ji Won Oh, Eun-Shil Lee

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Differential Angiogenic Potential of 3-Dimension Spheroid of HNSCC Cells in Mouse Xenograft
International Journal of Molecular Sciences. 2021 Jul 31;22(15):8245. doi: 10.3390/ijms22158245.
So-Young Choi, Soo Hyun Kang, Su Young Oh, Kah Young Lee, Heon-Jin Lee, Sangil Gum, Tae-Geon Kwon, Jin-Wook Kim, Sung-Tak Lee, Yoo Jin Hong, Dae-Geon Kim, Su-Hyung Hong

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Differential Angiogenic Potential.jpg
Three-Dimensional Visualization With Tissue Clearing Uncovers Dynamic Alterations of Renal Resident Mononuclear Phagocytes After Acute Kidney Injury
Frontiers in Immunology. 2022 Mar 10;13:844919. doi: 10.3389/fimmu.2022.844919. eCollection 2022.
Kipyo Kim, Yun-Gyeong Kim, Su Woong Jung, Yang Gyun Kim, Sang-Ho Lee, Seung-Hae Kwon, Ju-Young Moon

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Deep Tissue Clearing for Three-dimensional Imaging Analysis of Murine Pancreas 
Anat Biol Anthropol. 2022 Jun;35(2):57-66.
Nanda Maya Mali, Jung Min Park, Gil-Hyun Kim, Dong-Hwa Choi, Raul Ramos, Jong Hyuk Lee, Eu Jeong Ku, Ji Won Oh

Read the paper in  the Anatomy & Biological Anthropology
Analysis of Murine Pancreas.jpg
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